Disease-associated single-nucleotide polymorphisms (SNPs) in the TNFAIP3 gene have been identified in genome-wide association studies (GWAS) in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type I diabetes, Crohn’s disease, celiac disease, primary biliary cirrhosis, systemic sclerosis, and psoriasis (1, 2). The gene discussed is TNFAIP3; the disease is Crohn disease.