F127C (rs2230926), located within the deubiquitinating region, renders TNFAIP3 modestly less effective at inhibiting TNF-α-induced NF-κB signaling, and one study associates rs2230926 TT homozygosity with lower mRNA levels and poorer outcome in RA (60, 63). The gene discussed is TNF; the disease is rheumatoid arthritis.