Nevertheless, EV-associated Flt-1 may still be an important contributor to the pathogenesis of preeclampsia because: (1) we have shown that increased numbers of micro- and nano-vesicles are extruded by PE placentae and (2) we have previously reported that different size fractions of EVs are targeted to specific maternal organs such as the kidneys and liver, organs that are affected in preeclampsia (52, 54). The gene discussed is FLT1; the disease is preeclampsia.