Therefore, while increased levels of free sFlt-1 may mediate global endothelial cell dysfunction by sequestering circulating VEGF, vesicle-associated Flt-1 may be concentrated in specific organs such that even a low circulating level of vesicle-associated Flt-1 may have a large biological significance by causing organ-specific endothelial cell damage, such as glomerular endotheliosis which is commonly reported in women with preeclampsia (3, 6). The gene discussed is VEGFA; the disease is preeclampsia.