Finally, we performed a detailed dose–response analysis measuring infarct size with differing doses of decernotinib, and found that inhibiting JAK3 is not neuroprotective in the acute phase of experimental ischemic stroke in the mouse (Figures 2A,B) since it had no significant effect on infarct size at 48 h regardless of the dose from 0.03 to 10 mg/kg. Here, JAK3 is linked to ischemic stroke.