TGFB1 and aortic aneurysm: We show that myocardin, TGF-β, BMP and Notch–related mechanisms of SMC differentiation are attenuated in the smooth muscle cells of the patients with thoracic aortic aneurys; Notch-dependent and proosteogenic genes show distinct expression in smooth muscle cells of BAV- vs. TAV-related aortic aneurysms.