As in DCM, NLRP3 inflammasome also plays an important role in myocardial ischemia/reperfusion (I/R) injury after high-fat high-fructose (HFHF) diet, which is a common type of cardiometabolic disease (Mastrocola et al., 2016a). This evidence concerns the gene NLRP3 and familial dilated cardiomyopathy.