Taken together, these reports demonstrate the involvement of APEH activity in the modulation of synaptic activity (Olmos et al., 2009), its localization in synapses of the rat telencephalon (Sandoval et al., 2012), and the ability of the enzyme found in the conditioned medium of neuroblastoma cells to degrade monomers, dimers, and trimers of the Aβ1-40 peptide (Yamin et al., 2007, 2009). Here, APEH is linked to neuroblastoma.