MAPT and early-onset autosomal dominant Alzheimer disease: In the recent study by Mattsson et al. using SIMOA to measure tau, the results showed mean values at 2.58 pg/ml in NCs and 3.12 pg/ml in ADs in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort, and 5.58 pg/ml in NCs and 5.37 pg/ml in ADs in the Swedish Biomarkers for Identifying Neurodegenerative Disorders Early and Reliably (BioFINDER) study cohort.