MAPT and Alzheimer disease: Plasma or serum Aβ species and tau levels measured by conventional ELISA assays have been inconsistent in demonstrating disease-associated differences due to assay sensitivity and the wide data overlap between groups (Sparks et al., 2012; Chiu et al., 2013, 2014; Zetterberg et al., 2013; Krishnan and Rani, 2014; Tzen et al., 2014) The application of IMR and SQUID technology for AD blood biomarker development has been a recent invention (Yang et al., 2011; Chiu et al., 2012, 2013, 2014).