It has been demonstrated that different types of ketogenic diets represent alternative treatment methods (metabolic-based therapies) for a broad range of seizure disorders, in which decreased epileptic activity may be related to elevations in serum ketone bodies, reduced glucose levels, suppression of insulin signaling as well as different neurotransmitter systems, such as GABAergic and adenosinergic system in different types of epilepsies (Ross et al., 1985; Van Delft et al., 2010; Sharma et al., 2015; Rho, 2017). Here, INS is linked to epilepsy.