Subgroup analyses demonstrated that Foxp3+ T lymphocytes were a poor predictor of OS and DFS/RFS in studies regardless of the number of patients (≥200 vs. <200), percentage of HBsAg(+) patients (≥90% vs. <90%), percentage of patients with liver cirrhosis (≥80% vs. <80%), percentage of Child-Pugh score A patients (≥80% vs. <80%), percentage of TNM stage I-II patients (≥70% vs. <70%), percentage of patients with multiple tumors (≥30% vs. <30%), and percentage of vascular invasion (≥50% vs. <50%). Here, FOXP3 is linked to cirrhosis of liver.