It is worth noting that the positive rate of anti-SmD1 antibodies (56.80%) in non-naive SLE patients was significantly higher than that of anti-dsDNA antibodies (44.97%), but this difference was not been found in naive SLE patients (68.00% and 59.00%), which indicated the importance of detection of anti-SmD1 in non-naive SLE. This evidence concerns the gene SNRPD1 and systemic lupus erythematosus.