The concentrations of anti-SmD1, anti-Sm, and anti-dsDNA in the serum of treated naive SLE patients was significantly lower than that in the serum before treatment (t = 2.54, P = 0.039; t = 2.49, P = 0.042; t = 3, 24, P = 0.014, respectively). Here, SNRPD1 is linked to systemic lupus erythematosus.