For example, Egr2, not annotated as a CV gene yet, was differentially expressed at the beginning of TAB-induced cardiac hypertrophy and ~42% of its targets are CV genes, two of which, Fibroblast growth factor 8 (Fgf8) and Noggin (Nog), have been reported to negatively regulate cardiac muscle tissue development37, 38. This evidence concerns the gene NOG and cardiac hypertrophy.