Our previous studies have demonstrated that a combination of low-dose DDP with gene therapy expressing tumor protein p53 (p53) and mouse double minute 2 homolog (MDM2) siRNA, delivered by attenuated Salmonella enterica serovar Typhi vaccine strain Ty21a (Salmonella Typhi Ty21a), synergistically inhibited ovarian cancer and PCa growth without damaging normal tissues22–25. The gene discussed is MDM2; the disease is posterior cortical atrophy.