Hypertension is chosen because of three reasons: (i) hypertension is known for being involved in multi-body parts such as kidney, myocardium, and adrenal glands, (ii) the mechanism of hypertension is associated with intercellular associations like renin-angiotensin system23, (iii) some GO terms like ‘sodium ion binding’ are related to the mechanism of hypertension24. Here, REN is linked to hypertensive disorder.