PRDM9 and North Carolina macular dystrophy: Recently, disrupted developmental expression of the transcription factor and histone methyltransferase PRDM1330, 31 was suggested as a disease mechanism for NCMD at the 6q16 locus, based on the identification of non-coding SNVs and duplication events residing in an overlapping region upstream of PRDM13 in many MCDR1 families.