PYCARD and psoriasis: Next, we studied components of the autophagosome (WIPI122) and several innate receptors (IFIH1, AIM2) and inflammasome components (NLRP1, NLRP3, PYCARD, CASP1) in the skin of psoriasis patients in comparison with control subjects, as autoinflammatory diseases are often associated with inflammasome activation in response to stress signals (Fig. 3a, Supplementary Fig. S4).