LIG4 and Nijmegen breakage syndrome: The finding that antioxidants, particularly EDHB, improved genomic stability of NBS-iPSCs can improve reprogramming of additional NBS fibroblasts and other diseases like NBS which derive from mutated genes in DNA repair pathways, examples include, Fanconi Anemia (FA)16, Ligase IV (LIG4) syndrome17, Bloom syndrome18, NBS-like disorder19, Ataxia-Telangiectasia-Like Disorder (ATLD)20, Nonhomologous end-joining factor 1 (NHEJ1) syndrome21 and Seckel Syndrome22.