We have previously reported that purinergic P2Y6 receptor-α subunit of G12/13 (Gα12/13) protein signaling initiates TAC-induced cardiac fibrosis in mice38, and the activation of Gα13 increases expression of these cytokines in a NF-κB-dependent manner in rat cardiac fibroblasts39. Here, NFKB1 is linked to persistent truncus arteriosus.