In addition, hyperglycemia induced by the treatment with streptozotocin (STZ), a compound that has a preferential toxicity toward pancreatic β cells, is shown to upregulate TRPC6 in mouse heart, and that the upregulated TRPC6 negatively regulates STZ-induced oxidative stress through destabilizing Nox2 protein by counteracting the formation of the stable TRPC3-Nox2 complex. Here, TRPC6 is linked to Hyperglycemia.