MTOR and neoplasm: This is a surprising finding because YAP mediates crosstalk between the Hippo and phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways and it activates the mammalian target of rapamycin (mTOR), signaling pathways that are important for the promotion of tumor proliferation, migration, and apoptosis40–42, 49.