PINK1 and Parkinson disease: Other investigators have demonstrated that blocking Drp1 function is protective in PD cell culture models of PINK123, LRRK249, 50 or VPS3526 mutations, and of rotenone51, MPP+ 52, 53 or 6-hydroxydopamine54 neurotoxins, as well as in Pink1−/− and MPTP-treated mice1.