VPS35 and Parkinson disease: Of the six PD-related genes that we targeted, several have been directly linked to the autophagy/lysosomal pathway; mutations in catp-6 (atp13a2) and lrk-1 (lrrk2) have been shown to impair autophagy41–43, while mutant vps-35 impairs the ability of the retromer to deliver essential lysosomal enzymes, impacting lysosomal function44.