We therefore performed single nuclear RNA-sequencing of PCM1+ (pericentriolar material 1) CM nuclei isolated from the left ventricles of transverse aortic constriction (TAC) mouse model of heart failure and Sham-operated control mice, as well as human end-stage failing hearts (non-ischemic dilated cardiomyopathy: DCM) and age- and sex-matched healthy controls. Here, PCM1 is linked to familial dilated cardiomyopathy.