To characterize the effects of p53 mutants in lung adenocarcinoma, we generated KrasG12D-driven murine tumors that either lack p53 (p53Fx allele; i.e., p53−) or carry a contact (p53R270H) or conformational (p53R172H) mutation (Jonkers et al. 2001; Jackson et al. 2005). This evidence concerns the gene TP53 and lung adenocarcinoma.