In the immunohistochemical staining, the tumor cells of SSC-1 were strongly positive for p53, TGF-β1, c-erbB2, caspase-9, PARP, FAS, FASL, MMP-2, and MMP-9, while the tumor cells of SSC-2 were strongly positive for KRAS, STAT3, MPM2, eIF5A, DHS, DOHH, snail, and survivin. This evidence concerns the gene STAT3 and neoplasm.