In the protein expression profile of SSC-1, the neoplastic proliferation of tumor cells was supported by the overexpression of E2F-1 and c-erbB2, and the cellular transformation and differentiation of tumor cells were related to the overexpression of TGF-β1, TGase-1, HO-1, hTERT, and p38 compared to SSC-2. The gene discussed is E2F1; the disease is neoplasm.