In the immunohistochemical staining, the SSC-1 tumor cells were strongly positive for p53 (Fig. 2 A3), TGF-β1, c-erbB2, caspase-9, PARP, FAS, FASL, MMP-2, and MMP-9, while the SSC-2 tumor cells were strongly positive for KRAS (Fig. 2 B3), STAT3, MPM2, eIF5A, DHS, DOHH, snail, and survivin (data not shown). The gene discussed is DOHH; the disease is neoplasm.