In addition to HIF-1α, systematic ChIP-seq data of human hypoxic breast cancer cells revealed that, HIF-2α also bound with lncRNA promoters and even in a higher proportion than HIF-1α, suggesting a pivotal role of HIF-2α in the regulation of the long noncoding transcriptome upon hypoxia [50]. The gene discussed is EPAS1; the disease is breast carcinoma.