TNF and type 2 diabetes mellitus: Also in T2D inflammatory circulating molecules as C-reactive protein (HsCRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), together with abnormal endothelial expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) support a low-grade chronic state of inflammation and contribute to progression of disease and its complications providing prognostic information on clinical outcomes [4].