Interestingly recent studies indicate that OPG is an important regulatory molecule in vascular diseases, including cerebral atherosclerosis, and contributes to vessel calcifications in T2D patients, thus suggesting an its possible role in progression of atherosclerotic lesions of other vascular beds such as lower extremity PAD of patients affected by diabetes [17, 18]. This evidence concerns the gene TNFRSF11B and peripheral arterial disease.