APP and Alzheimer disease: This APPswe/PS1dE9 (APP.PS1; MGI ID: 3524957) AD model mouse strain was engineered to express murine App with the human Aβ amino acid sequence harboring mutations that cause a familial form of AD (the Swedish mutation APPK595N/M596L; APPswe) together with a mutated form of PSEN1 (PS1 with exon 9 deleted; PS1dE9) [115].