A tendency for higher Chromogranin A expression in less-differentiated tumor areas (reflected by a higher Gleason pattern (GP)) was observed in the primary tumors (GP3: 0.8% mean of Chromogranin A positive cells; GP4: 1.0%; GP5: 1.4%; p > 0.05) and in the nodal metastases (GP3: 0.0%; GP4: 1.8%; GP5: 7.8%; P = NE), but no statistical significance was reached (Figure 1B). The gene discussed is GP5; the disease is neoplasm.