In the UK Biobank, we found that the rare C-allele at IL33-rs146597587 associated with reduced eosinophil count is also associated with lower risk of asthma (P = 2.60x10-7, odds ratio = 0.56) and allergic rhinitis (P = 4.21x10-4, odds ratio = 0.55) (Table 3). The gene discussed is IL33; the disease is asthma.