SOX2 and basal cell carcinoma: Of note, Basal Cell Carcinoma Signaling is closely related to Sonic Hedgehog (SHH) Signaling, which has been associated with the carcinogenesis of SCCs of the oral mucosa, uterine cervix, esophagus and lung [32–35], where it may have a role in mediating stemness via transcription factors like SOX2 [34,35].