DSC3 and cancer: Other notable genes relatively upregulated in SCCs were keratins KRT14 and KRT17; DSC3, a member of the desmocollin family (a component of intercellular desmosomes); FAT2, an atypical cadherin found to be induced by ΔNp63α (isoform of TP63) and promote invasion in LUSC [16]; EGFR, a key growth factor receptor in many cancers; CCNA1, which encodes for cyclin A1, a cell cycle regulator; and WNT3A, a member of the Wnt family of signaling proteins, which also may have a role in SCCs [17].