In addition, we identified candidate genes that correlate with patient outcomes and may have a functional role in ADC carcinogenesis, such as IGF2BP1. Intriguingly, increased IGF2BP1 expression was found to be associated with worse survival in EAC, LUAD, and a pooled dataset of other ADCs spanning breast to colon (Fig 6C–6F). Here, IGF2BP1 is linked to AIDS dementia complex.