Nevertheless, the fact that insoluble Tau levels are elevated only in the homozygous but not heterozygous KI mice (with the exception of the RZ3 antibody), whereas cognitive deficits in novel object recognition and water maze were detected in both would appear to suggest that these behavioral deficits are not dependent on accumulation of insoluble phosphorylated Tau. Here, MAPT is linked to Cognitive impairment.