In a rodent model of maternal UN, a combination treatment with GH and the lipid lowering agent acipimox resulted in an enhancement of linear growth in both control and maternally undernourished male offspring, and prevented the hyperinsulinemia that resulted from GH treatment alone; these effects of acipimox may be mediated in part by inducing a direct decrease in free fatty acids that are known to inhibit GH responsiveness to a range of pharmacological and physiological stimuli [39,40]. This evidence concerns the gene GH1 and Hyperinsulinemia.