The distribution of pituitary adenomas according to their function was prolactinoma (PRL) in 10 (7.2%) cases, acromegaly (GH) in 37 (27.0%) cases, Cushing disease (ACTH) in 4 (2.9%) cases, thyrotropinoma (TSH) in 1 (0.7%) case, non-functioning adenoma (NF) in 57 (41.6%) cases, PRL + GH in 1 (0.7%) case and not determined (ND) in 27 (19.7%) cases. The gene discussed is GH1; the disease is TSH-secreting pituitary adenoma.