Secondary tumor developed in PRL, ACTH, GH, NF pituitary adenomas 9, 7, 11, and 14 years after irradiation, respectively (GH vs. NF, p = 0.0386; ACTH vs. NF, p = 0.1786; PRL vs. NF, p = 0.8318) (Figure 2B). This evidence concerns the gene PRL and pituitary gland adenoma.