Besides MMP2, MMP7, and MMP9, transmembrane collagenase MT1-MMP/MMP14, which is particularly associated with cell protrusions such as invadopodia, represents a key enzyme in remodeling ECM by driving invasion of tumor cells via degradation of collagen type I and thereby facilitating dissemination of cancer cells [40, 56–59]. This evidence concerns the gene MMP14 and neoplasm.