Another important genetic aberration associated with glioblastoma and mentioned in the 2016 WHO classification is the amplification of epidermal growth factor receptor (EGFR) gene, also referred to as (ERBB1 or HER1). EGFR, localized on 7p12, encodes a membrane receptor tyrosine kinase which is bound by EGF ligand. Here, EGF is linked to glioblastoma.