PROM1 and cancer: For example, N-(2-hydroxypropyl) meth acrylamide (HPMA) conjugate of cyclopamine (a Hedgehog pathway inhibitor) has been reported showing potential to eradicate CD133+ cells in the human prosthetic cancer epithelial cell line (RC-92a/hTERT) and exhibit relatively decreased systemic cytotoxicity (Zhou et al., 2012).