POMC and Adrenal insufficiency: Relative adrenal insufficiency shows as a lack of enough raise in cortisol levels to ITT or to ACTH-stimulation test; GH deficiency is diagnosed when a blunted GH is observed to ITT; and pre-diabetes or initial diabetes are more accurately diagnosed by Oral Glucose Tolerance Test, which provides earlier information about disglycemia than fasting serum glucose, once relative hypoinsulinemia with consequent hyperglycemia in response to oral glucose is observed.