In fact, the mean level of 2KG was not altered in the IDH1 or 2 mutant acute myeloid leukemia (AML) [62] or glioma cells [40], suggesting that the mutation does not decrease the concentration of this metabolite, a finding that does not support the tumor suppressor role of IDH1 or 2. The gene discussed is IDH1; the disease is acute myeloid leukemia.