It could also explain why in most tumor types neomorphic IDH1 alleles are more common than those of IDH2, except in AITL where neomorphic IDH1 alleles has not been reported and AML where neomorphic IDH1 and IDH2 alleles have similar frequencies [104, 114, 115, 152, 153]. This evidence concerns the gene IDH2 and acute myeloid leukemia.