IDH1 and central nervous system cancer: Recently, the effects of IDH1 R132 and IDH2 R172 mutations on hematopoietic cell lines were replicated using exogenously applied (D)-2HG, not to mention that IDH inhibitors were found to reduce (D)-2HG production and inhibit the growth of leukemia or glioma cells in a mutant-specific manner, proving that this metabolite mediate IDH1 R132 and IDH2 R172 mutated alleles oncogenicity [58, 65–68].