Therefore, supplementation of zinc could affect the transcription of DNA and telomere length by activation of p53 in hepatoma cells.48 According to the aforementioned reports, in the present study, it was suggested that ADSCS aging prevention in the presence of ZnSO4 may be due to changes in TERT gene expression, telomerase activity, telomere structure and telomere length. Here, TERT is linked to hepatocellular carcinoma.