SCNN1A and endothelial dysfunction: Although it cannot be excluded that aldosterone, apart from activating ENaC also activates other pathways possible leading to endothelial dysfunction (43), and that large vessel endothelial cells, as investigated in the Kusche-Vihrog studies, are phenotypically different from microvascular endothelial cells, our results indicate that ENaC-α participates in barrier strengthening in HL-MVEC at least partially in the context of a complex different from classical ENaC.