TLR4 and asthma: Inhibition of miR-126 has been tried in mouse models of asthma, showing that regulation of this miRNA targets toll-like receptor 4 (TLR4) through upregulation of transcription factor PU.1 and upregulation of target of Myb protein 1, blocking IL-1β and TNF-α and thus inhibiting the asthmatic inflammation phenotype (130, 131).