IL13 and asthma: Eosinophils play a central role in asthma pathogenesis, releasing an array of pro-inflammatory cytokines (IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, IL-16, IL-18, and TGF-α/β), chemokines (RANTES and eotaxin-1), and lipid mediators (LTC4, platelet-activating factor, thromboxane B2, and prostaglandins) that orchestrate the processes and symptoms of the disease (65, 66).