TNF and autoimmune disease: Biological drugs targeting IL-1 (anakinra), Th1 immune responses (IL-12/IL-23, ustekinumab), Th17 immune responses (IL-17, secukinumab) and CD20 (rituximab) have also been approved for the treatment of autoimmune diseases, as summarized in the Table 2, as a complementary and alternative biological treatment of anti-TNF therapy.