More importantly, these results suggest that examination of the total epigenetic landscape of the SLC1A2 gene may provide a useful clinical tool for the accurate diagnosis of BD and BD comorbidities and that individual point methylation within the promoter region of a gene encoding for glutamate transporter may be modified by addiction which in a sequence of downstream events could lead to associated functional change in glutamate tone (Zschocke et al., 2007). Here, SLC1A2 is linked to Behcet disease.