Additionally, a number of in vivo studies have demonstrated the association of EAAT2 and glutamate clearance dysregulation to the pathophysiology of BD and addiction (Miguel-Hidalgo et al., 2010; Ruby et al., 2010; Dallaspezia et al., 2012; Poletti et al., 2014). This evidence concerns the gene SLC1A2 and Behcet disease.