Alternatively, it is possible that different patterns of methylation may promote alternative splicing of the EAAT2 mRNA, which may alter the subcellular localization and functionality of the mature protein and result in similar impairment as a result of hypermethylation in BD or hypomethylation in BD with addiction (Maragakis et al., 2004; Berger et al., 2005; Lauriat and McInnes, 2007). Here, SLC1A2 is linked to Behcet disease.