Since it has been demonstrated that treatment with P2X7 receptor antagonist and IL-1β antibody could also reduce thalamic hemorrhage-induced microglia aggregation, neuronal excitability and allodynia phenomena in CPSP rats (Kuan et al., 2015), a common upstream regulation by HIF-1α-SDF1-CXCR4 signaling might be shared. The gene discussed is CXCL12; the disease is hemorrhage.