Interestingly, according to the germinal layers that derived from extranodal lesions in DLBCL patients, JAM-A overexpression was associated with mesoendoderm-derived organs (intestine, n = 15, stomach, n = 11, liver, n = 7, bone, n = 5, lung, n = 4, etc.), instead of ectoderm-derived organs (breast, n = 4, sensory organs, n = 3, etc.)(endoderm vs ectoderm, P = 0.0431, mesoderm vs ectoderm, P = 0.0320, Fig. 4E). The gene discussed is F11R; the disease is diffuse large B-cell lymphoma.