FGFR3 and achondroplasia: Yamashita et al. 10 demonstrated that statins rescued the dwarf phenotype of ACH mouse model by using induced pluripotent stem (iPS) cells established from patients with gain-of-function mutations in FGFR3. A specific inhibitor for FGFR3, NVP-BGJ398, not only increased longitudinal bone growth but also ameliorated the foramen magnum stenosis in mouse model of ACH11.