By using two different mouse lines carrying Umod mutations (UmodC93F, UmodA227T) induced by N-ethyl-N-nitrosourea (ENU), Kemter et al. showed that inflammation could play a role in models of ADTKD-UMOD, via activation of NF-kB pathway in TAL segments39. Here, NFKB1 is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.