Both MYBL2 and FoxM1 siRNAs down regulated the protein levels of N-cadherin and Vimentin but increased the levels of E-cadherin and ZEB1 (Fig. 4h).We also detected the effects of MYBL2 and FoxM1 on MMP activity which has been closely correlated with degradation of basement membrane and invasion of cancer cells. This evidence concerns the gene FOXM1 and cancer.