In the present study, the tandem polymorphisms (rs148314165, rs200820567), a pair of tandem polymorphic dinucleotides (deletion T followed by a T to A transversion), which were demonstrated to influence A20 expression through interfering with the delivery of NF-kB to the TNFAIP3 promoter [22, 23], were examined in chronic HBV infection and HBV-related liver diseases. The gene discussed is NFKB1; the disease is liver disorder.