In view of the connection between A20 and HBV [11], HBV infection [12], liver inflammation [14], and HCC [16, 17], and the influence of TNFAIP3 polymorphisms on A20 function and expression [18, 19, 22, 23] and liver regeneration [18], the TNFAIP3 polymorphisms in patients with chronic HBV infection were investigated. This evidence concerns the gene TNFAIP3 and hepatocellular carcinoma.