IL6 and cancer: There was also a gradient increase in the intracellular IL-6 level in RAB3C-overexpressing cells after treatment with 50 μM and 100 μM EXO1, an exocytosis inhibitor, as well as the finding that blocking IL-6 with IL-6 antibody added to the maintenance medium significantly decreased the migration ability of RAB3C-overexpressing cells in a dose-dependent manner, indicated that RAB3C regulates cancer metastasis through IL-6 exocytosis (Fig. 5c and d).