Of all the 215 colorectal cancer patients, high RAB3C expression level defined by moderate to strong cytoplasmic RAB3C IHC staining was observed in 125 (58.1%) cases, and low RAB3C expression level defined by negative or weak cytoplasmic RAB3C IHC staining was observed in 90 (41.9%) cases (Fig. 1c and d). The gene discussed is RAB3C; the disease is colorectal cancer.