The percentage of men 50 years old and over who reported PSA screening decreased from 40.6% in 2008 to 30.8% in 2013 and the incidence of prostate cancer in men 50 and over declined from 540.8 per 100.000 men in 2008 to 416.2 per 100.000 men in 2012. The gene discussed is KLK3; the disease is Familial prostate cancer.